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Abstract
This past year the 160th anniversary of the discovery of nitrous oxide as an analgesic/psychotropic anesthetic by an American dentist, Horace Wells, was celebrated in Hartford, Connecticut, USA. This useful gas has been in continuous use longer than any other anesthetic agent and has withstood the test of time. Applications in clinical practice over a variety of health disciplines are presented. This article provides technique guidelines for the administration of nitrous oxide/oxygen sedation to maximize and to customize individual gas dosages for optimal psychotropic and analgesic efficacy. Titration will be discussed with the intent for this manuscript to enable the proper concepts for nitrous oxide/oxygen administration and to customize individual gas dosages to achieve optimal doses of nitrous oxide consistent with psychotropic analgesic nitrous oxide (PAN).