AN OLFACTORY BULBECTOMY MODEL TO STUDY PLASTICITY OF THE NERVOUS SYSTEM IN RAT: A REVIEW FOCUSED ON PUBLISHED DATA FROM THE SLOVAK REPUBLIC

Abstract

This review surveys the main data published at the Institute of Neurobiology, Slovak Republic, pertaining to both morphological and functional observations in the olfactory bulbectomy model. The review utilized this experimental approach in homo- and heterotopic transplantations, in experiments for studying neurodegenaration/regeneration and phenomena of adult neurogenesis. The results, discussed in context of relevant literary data, indicate that the model of olfactory bulbectomy can be utilized to investigate problems not only related to the olfactory system but it can also address the problems of neuronal development, neuronal plasticity and interaction concerning the nervous system as a whole.

Keywords:

• functional recovery
• homo- and heterotopic neurotransplantation
• neonatal/adult neurogenesis
• olfaction
• olfactory bulbectomy
• regeneration