THE EFFECT OF PROGESTERONE ON TOTAL BRAIN TISSUE SIALIC ACID LEVELS IN EXPERIMENTAL EPILEPSY

SADRETTIN PENCE Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey

MEHMET BOSNAK Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey

NACIYE KURTUL Department of Chemistry, Faculty of Science Sutcu Imam University, Kahramanmaras, Turkey

METE GUROL UGUR Department of Obstetrics & Gynecology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey

IBRAHIM ERKUTLU Department of Neurosurgery, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey

CAHIT BAGCI Department of Physiology, Faculty of Medicine University of Gaziantep, Gaziantep, Turkey

UNER TAN Department of Physiology, Medical School Cukurova University, Adana, Turkey

show all

Abstract

Epilepsy, the most common neurological disorder worldwide, changing cellular interactions and connectivity may have effects on sialic acid levels. A total of 80 mice were separated into 8 groups: the sham, control, pentylentetrazole (PTZ), PTZ plus progesterone, five dose progesterone, single dose progesterone, kindling, and kindling plus progesterone groups. Brains of each mice were extracted and were divided into five parts. The sialic acid levels were significantly different between the groups and also in the subgroups. The results suggested that progesterone may have an anti-seizure effect by decreasing sialic acid levels in mice. Further studies are needed to evaluate the role of progesterone on sialic acid levels and its role in the epilepsy pathogenesis.

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

THE EFFECT OF PROGESTERONE ON TOTAL BRAIN TISSUE SIALIC ACID LEVELS IN EXPERIMENTAL EPILEPSY

Information for

Open access

Opportunities

Help and information

THE EFFECT OF PROGESTERONE ON TOTAL BRAIN TISSUE SIALIC ACID LEVELS IN EXPERIMENTAL EPILEPSY

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature