APOLIPOPROTEIN E PHENOTYPE IN DEMENTED PATIENTS IN GREEK POPULATION

ELENI HATZIFILIPPOU Neuropathological Laboratory of the 1st, Department of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece

TANIA BANAKI Memory Clinic of the 1st, Department of Neurology, Aristotelian University, Thessaloniki, Greece

MARIA TRAKA Memory Clinic of the 1st, Department of Neurology, Aristotelian University, Thessaloniki, Greece

EPHROSYNI KOUTSOURAKI Neuropathological Laboratory of the 1st, Department of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece; Memory Clinic of the 1st, Department of Neurology, Aristotelian University, Thessaloniki, Greece

VASSILIKI COSTA Neuropathological Laboratory of the 1st, Department of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece; Memory Clinic of the 1st, Department of Neurology, Aristotelian University, Thessaloniki, Greece

STAVROS J. BALOYANNIS Neuropathological Laboratory of the 1st, Department of Neurology, Aristotelian University, AHEPA Hospital, Thessaloniki, Greece; Memory Clinic of the 1st, Department of Neurology, Aristotelian University, Thessaloniki, Greece

Abstract

Apolipoprotein E is a plasma protein, involved in the transport of lipids and their metabolism. The aim of this investigation was to correlate the ApoE phenotypes with the type and the severity of dementia in Greek demented patients.

The investigation revealed that 72% of the patients have the E3/3 phenotype, but only 11% of them demonstrated the E3/2; 13% of the patients have the E4/3 phenotype and only 4% of them demonstrated the phenotype E4/4. The most severely demented patients corresponded to e4 alléle. The present results indicate that the most common ApoE phenotype in Greek demented patients is E3/3.

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APOLIPOPROTEIN E PHENOTYPE IN DEMENTED PATIENTS IN GREEK POPULATION

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APOLIPOPROTEIN E PHENOTYPE IN DEMENTED PATIENTS IN GREEK POPULATION

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