Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT_1a Receptor Subtype

Galina Idova Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

Svetlana Davydova Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

Elizaveta Alperina Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

Margarita Cheido Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

Lidia Devoino Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia

Abstract

The present study demonstrates the involvement of serotonin (5-HT) receptors of the 5-HT_1A type in immunoinhibitory effect of 5-HTergic system of the brain. A selective agonist of 5-HT_1A receptors 8-OH-DPAT (1 mg/kg) induces the immunosuppression, whereas 5-HT_1A blockade with WAY-100635 (1 mg/kg) resulted in immunostimulation. It is also shown that immunomodulating effects of the drugs were dependent on psychoemotional status of animals acquired aggressive or submissive behavior under social conflict conditions. Activation of 5-HT_1A receptors produced a decrease of the immunity in aggressive mice, whereas 5-HT_1A receptor blockade caused immunostimulation in submissive animals.

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Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT_1a Receptor Subtype

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Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT1a Receptor Subtype

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Serotoninergic Mechanisms of Immunomodulation Under Different Psychoemotional States: I. A role of 5-HT_1a Receptor Subtype