Magnetic Brain Stimulation Upregulates Adhesion and Prevents Eae: MMP-2, ICAM-1, and VCAM-1 in the Choroid Plexus as a Target

Abstract

Clinical signs appearance and significant increases of ICAM-1 and MMP-2 expressions with the clusters of VCAM-1⁺ immunoreactivity in the choroids plexus epithelium to transferred anti-myelin oligodendroglial antibodies into the third brain ventricle, indicate important role of choroids plexus in the induction of acute experimental autoimmune encephalomyelitis (EAE). Magnetic brain stimulation with AKMA micro-magnet flux density of 60 miliTesla, 5 mm in diameter, implanted upon the pineal gland (PG), immediately after antibody injection, significantly decreases the expression of MMP-2 and ICAM-1 in the choroids plexus of the rat brain and abruptly suppresses the induction of acute EAE.

Keywords:

• adhesion
• choroids plexus
• EAE induction
• magnetic stimulation
• rats