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International Journal of Neuroscience Volume 119, 2009 - Issue 2
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Original

Pien Tze Huang, a Composite Chinese Traditional Herbal Extract, Affects Survival of Neuroblastoma Cells

Lanhai Lü Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University Guangzhou, Guangdong, China
,
Maria S. M. Wai Department of Anatomy, Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
,
David T. Yew Department of Anatomy, Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
&
Ying T. Mak Department of Anatomy, Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
Pages 255-262 | Received 28 Mar 2008, Published online: 24 Aug 2009
 
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Abstract

Pien Tze Huang is a popular Chinese medicine for liver diseases. In the investigations of possible effects of Pien Tze Huang on the central nervous system, we first studied the in vitro anti-cancer activity of Pien Tze Huang on neuroblastoma cells (SH-SY5Y) as compared with normal fibroblasts (NIH-3T3). Results showed that Pien Tze Huang significantly decreased (p < .05) cell survival of SH-SY5Y as compared to NIH-3T3. Furthermore, the decreases in cell survival of SH-SY5Y were significantly and linearly dose-dependent (p < .05) from 400 to 1,000 μg/ml. This supports further in vivo and animal studies for anti-cancer effect, neuroprotection, and theirmechanisms.

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