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Review Articles

Isolated brainstem involvement in posterior reversible encephalopathy syndrome: a case report and review of the literature

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Pages 808-813 | Received 10 Jul 2018, Accepted 10 Dec 2018, Published online: 17 Feb 2019
 

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a clinical–radiological syndrome, reversible vasogenic edema predominantly within parieto-occipital regions. However, isolated brainstem involvement in PRES has been rarely reported, little is known about its clinical manifestations, radiological features and outcomes. We reported a case with PRES with only brainstem involvement and performed a systematic review of published cases. Twenty-four cases, together with our case, were included in the analysis. Mean age was 43 years and 63% were males. Hypertension (50%), nephropathy (25%) and chemotherapy (21%) were the major risk factors. All patients except two had acute hypertension and 50% of patients had renal dysfunction at onset. The most common symptoms were altered consciousness (46%) and headache (46%), Seizure was only presented in 21% of patients. All patients except two were treated with antihypertension. Most patients recovered to their neurological baseline. Clinicians should recognize this unique variant finding in PRES. which always affects males with severe hypertension, especially combined with renal dysfunction. Antihypertensive treatment is the most widely used therapy. Outcome is usually well.

Disclosure statement

There are no financial disclosures or conflict of interest to report. The authors alone are responsible for the content and writing of this paper.

Additional information

Funding

This research was supported by grants from the Clinical Research Physician Program of Tongji Medical College, HUST (2017).

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