Noradrenergic pathways of locus coeruleus in Parkinson’s and Alzheimer’s pathology

Abstract

Noradrenergic system of brain supplies the neurotransmitter noradrenalin throughout the brain through widespread efferent projections and play pivotal role in cognitive activities and could be involve in motor and non-motor symptoms of Parkinson’s disease (PD) pathology. Profound loss of noradrenergic pathways has been reported in both Parkinson’s and Alzheimer’s disease (AD) pathology however their employment in therapeutics is still scarce. Therefore the present review is providing the various aspects for involvement on noradrenergic pathways in PD and AD pathology as well as the imaging of locus coeruleus as indicative diagnostic marker for disease. The present review is describing about the role of tiny nucleus locus coeruleus located noradrenergic pathways in said pathologies and discussing the past research as well as lacunas in this regard.

Keywords:

• Locus coeruleus
• Alzheimer’s disease
• neurodegenerative diseases
• Parkinson’s disease

Disclosure statement

Author has no conflict of interest. Research does not include Human Participants and/or Animals.