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Original Articles

Association between methylene tetrahydrofolate reductase polymorphisms and risk of ischemic stroke

, , , , , , & show all
Pages 44-48 | Received 28 Dec 2018, Accepted 11 Feb 2020, Published online: 26 Feb 2020
 

Abstract

Background: The methylene tetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme which catalyzes the conversion of homocysteine to methionine. Two single nucleotide polymorphisms (SNPs) within this gene namely rs1801133 (C677T) and rs1801131 (A1298C) have been associated with elevated risk of ischemic stroke and total serum homocysteine in some populations.

Aim: To assess associations between MTHFR SNPs and risk of ischemic stroke in Iranian population.

Methods: In the current case-control study, we genotyped rs1801133 and rs1801131 SNPs in 318 Iranian patients with history of ischemic stroke and 400 age- and sex-matched controls using tetra-primer amplification refractory mutation system-polymerase chain reaction method.

Results: The rs1801133 was significantly associated with risk of stroke in recessive model (OR (95% CI) = 1.89 (1.12–3.20), p = 0.03). The CT haplotype (rs1801131 and rs1801133, respectively) was significantly over-represented in patients compared with controls (OR (95% CI) = 1.71 (0.25–2.32), p = 0.002).

Conclusion: Consequently, our data demonstrate contribution of MTHFR variants in risk of ischemic stroke in Iranian population.

Disclosure statement

The authors declare they have no conflict of interest.

Additional information

Funding

The current study was supported by a grant from Hamadan University of Medical Sciences (Grant number: 960129771).

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