Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson’s disease: a meta-analysis

Abstract

Objective: Recent studies have found that selenium (Se) levels were associated with the risk of Parkinson’s disease (PD), but the results were contradictory. Therefore, this meta-analysis was conducted to investigate the correlation between Se levels and PD.

Methods: PubMed, Embase and Web of Science were searched published up to 28 October 2019. The differences between groups were analyzed by forest plots and results were pooled and assessed using a random-effect model. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to assess the association between Se levels and the risk of PD. Subgroup analysis, meta-regression, and sensitivity analysis were also conducted. Publication bias was estimated using Begg’s regression asymmetry test.

Results: Finally, 12 articles involving 601 PD patients and 749 controls were included in this meta-analysis. The meta-analysis revealed a significantly higher cerebrospinal fluid (CSF) Se level in PD patients than those in controls (SMD = 1.22; 95%CI [0.05, 2.39]; p = 0.000). No publication bias was found.

Conclusion: The meta-analysis indicated that CSF Se levels in PD patients were significantly higher than those in controls.

Keywords:

• Parkinson’s disease (PD)
• selenium
• cerebrospinal fluid
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Additional information

Funding

This work was supported by National Nature Science Foundation of China [grant number 81872626], Science and Technology Foundation for Innovation Talent of Henan Province [grant number 154200510010] and Science and Technology Plan of Henan Province [grant number 172102310029].