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Original Articles

Opportunities and challenges: mesenchymal stem cells in the treatment of multiple sclerosis

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Pages 1031-1044 | Received 17 Sep 2021, Accepted 09 Feb 2022, Published online: 17 May 2022
 

Abstract

Multiple sclerosis (MS) was once considered an untreatable disease. Through years of research, many drugs have been discovered and are widely used for the treatment of MS. However, the current treatment can only alleviate the clinical symptoms of MS and has serious side effects. Mesenchymal stem cells (MSCs) provide neuroprotection by migrating to injured tissues, suppressing inflammation, and fostering neuronal repair. Therefore, MSCs therapy holds great promise for MS treatment. This review aimed to assess the feasibility and safety of use of MSCs in MS treatment as well as its development prospect in clinical treatment by analysing the existing clinical studies.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Project of Health research talents Project of Jilin Province(2019sc2018; 20201231SY006) and the Project of Jilin Province Development and Reform Commission(2021C043-6) in China.

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