ABSTRACT
A review is given of oxygen carriage by embryonic hemoglobins of marsupial and eutherian mammals. It discusses results that have been published on embryonic blood of man, sheep, pig, rat, mouse, and rabbit among the eutherian mammals, and on embryonic-type blood of three marsupials—the tammar wallaby (Macropus eugenii), the brushtail possum (Trichosurus vulpecula), and the fat-tailed dunnart (Sminthopsis crassicaudata). The properties vary from species to species, but in eutherians the embryonic oxygen affinity is higher than in the mother's blood. In some species the affinity is higher than that of the fetal blood; in some it is lower. Marsupial embryonic-type blood has a low oxygen affinity. A lowered Bohr effect is nearly always found in embryonic blood. In whole blood of embryonic marsupials and rabbits there is a high cooperati vity of Hb-oxygen binding that is not found in hemoglobin solutions.