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ABSTRACT
Fish are the oldest vertebrates and the most divergent group, and therefore studies on developmental and molecular genetics in fish can provide a framework and reference for other vertebrates. The zebrafish embryo combines the advantages of experimental embryology and cell fate commitment as in amphibians with the genetic analysis of development as in mammalian systems. The zebrafish has very rapidly become a center of attention because of the thousands of induced developmental mutants that are currently in the process of isolation, characterization, mapping, and cloning. Together with more traditional approaches, like chromosomal and sex manipulation, the use of transgenic fish, and the attempts to produce targeted mutants in pluripotential fish embryonic stem cells, the field of molecular genetics of the fish embryo is now becoming the focus of studies on vertebrate development.