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Abstract
Pressure sensitive adhesives are a critical component in transdermal drug delivery systems (TDDS). In this study, styrene-isoprene-styrene triblock copolymers (SIS) was epoxidized with peroxyformic acid generated in situ. The hot-melt pressure sensitive adhesive (HMPSA) of ESIS with hydrogenated rosin, epoxidized soybean oil, and antioxidant was prepared. The structure and properties of ESIS were characterized with infrared spectroscopy and dynamic mechanical analysis (DMA). Water content and water vapor transmission rate on ESIS membranes were determined. The adhesion properties of HMPSA of ESIS were investigated. The experimental results showed that the HMPSA of ESIS was superior to traditional HMPSA of SIS in 180°peel strength when the substrates were polar materials, such as PVC and steel.
ACKNOWLEDGMENTS
The author is grateful to Major scientific and technological specialized project for “significant new formulation of new drugs ” (2009ZX09502) for partial support of the research reported here.
Notes
One of a Collection of papers honoring Wulff Possart, the recipient in February 2012 of The Adhesion Society Award for Excellence in Adhesion Science, Sponsored by 3M.