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Journal of Apicultural Research Volume 46, 2007 - Issue 2
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Original Articles

Inhibitory effect of bee venom against ultraviolet B induced MMP-11 and MMP-3 in human dermal fibroblasts

SangMi HanLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.Correspondence[email protected]
,
KwangGill LeeLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.
,
JooHong YeoLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.
,
HaeYong KweonLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.
,
SoonOk WooLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.
,
ManYoung LeeLaboratory of Applied Material Science, Department of Agricultural Biology, National Institute of Agricultural Science and Technology RDA, Suwon, 441-100, Korea.
,
Haju BaekGyeongsang Buk-Do Government Public Institute of Health and Environmental, Daegu, 701-702, Korea.
&
KwanKyu ParkDepartment of Pathology, Catholic University of Daegu School of Medicine, Daegu712-702, Korea.
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Pages 94-98 | Received 15 May 2006, Accepted 24 Apr 2007, Published online: 24 Mar 2015
 
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Summary

Ultraviolet-B (UVB) irradiation induced the synthesis of matrix metalloproteinase–1 (MMP–1) and stromelysin–1 (MMP–3) in skin fibroblasts, causing skin photoaging and skin tumor progression. The effect of honey bee venom (HBV) collected from Apis mellifera on the expression of MMP–1 and MMP–3 in UVB irradiated human dermal fibroblasts (HDF) was investigated. After UVB irradiation, HBV markedly reduced UV-induced MMP–1 by 50–80% and MMP–3 protein levels by 50–85 % compared with that of UVB-irradiated controls. It also reduced MMP–1 and MMP–3 mRNA expression. Furthermore, HBV accelerated the recovery of the damaged of UVB-irradiated HDF. These results suggest that HBV is a photoprotective agent and could be used as a potential agent in preventing photoaging.

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