Abstract
A test of statistical significance addresses the question, How likely is a result, assuming the null hypotheses to be true. Randomness, a central assumption underlying commonly used tests of statistical significance, is rarely attained, and the effects of its absence rarely acknowledged. Statistical significance does not speak to the probability that the null hypothesis or an alternative hypothesis is true or false, to the probability that a result would be replicated, or to treatment effects, nor is it a valid indicator of the magnitude or the importance of a result. The persistence of statistical significance testing is due to many subtle factors. Journal editors are not to blame, but as publishing gatekeepers they could diminish its dysfunctional use.