Synthesis of Thromboresistant Heparinized Polysilicone Using Radiation Grafting

Abstract

Gamma rays from ⁶⁰Co were used to graft chloromethylstyrene on samples of polysilicone, followed by quaternization with pyridine, then reaction with sodium heparin to replace chloride ions in the samples with heparin anions. Extraction tests on the heparinized samples with normal saline solution showed a maximum heparin removal rate of 5 × 10⁻-⁸ g/cm²/min. The heparinized polysilicone was found to be more blood compatible than untreated polysilicone in a rabbit ex vivo bleeding test.