Hydrolysis Reactions in Lamellar Liquid Crystalline Media and Octanol/Water Partition Coefficients

Abstract

Cationic lamellar liquid crystalline morphologies decrease rates of hydrolysis of a series of 4-substituted benzylidene t-butylamine N-oxides as the electron releasing effect increases and they are linear when plotted against o⁺- substituent constants. Rho-values indicate a more sensitive reactivity series in lamellar than in aqueous solvent. Reaction rates in the former solvent parallel the partition coefficients in octanol/water except for the rnethoxy-derivative.