Influence of Water Adsorbed on Avicel PH 101® on the Thermal Decomposition of p− Aminosalicylic Acid

E. Ben-rayana Université de Lausanne, Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, 3 Place du Chǎteau, CH-1005, Lausanne, SUISSE

A. Seddas Université de Lausanne, Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, 3 Place du Chǎteau, CH-1005, Lausanne, SUISSE

P. Ruelle Université de Lausanne, Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, 3 Place du Chǎteau, CH-1005, Lausanne, SUISSE

Hø Nam-Tran Université de Lausanne, Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, 3 Place du Chǎteau, CH-1005, Lausanne, SUISSE

U. W. Kesselring Université de Lausanne, Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, 3 Place du Chǎteau, CH-1005, Lausanne, SUISSE

Abstract

The importance played by the water adsorbed on Avicel PH 101® and, especially by its “unbound” fraction on the stability of PAS/Avicel PH 101® mixture is revealed in this work. Beyond the monolayer, any additional water uptake by the system induces an increase of the decarboxylation rate of p−aminosalicylic acid and a decrease of the apparent process activation energy, which tends towards the value obtained for aqueous solution.

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Influence of Water Adsorbed on Avicel PH 101® on the Thermal Decomposition of p− Aminosalicylic Acid

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Influence of Water Adsorbed on Avicel PH 101® on the Thermal Decomposition of p− Aminosalicylic Acid

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