Exploration of interactions between bioactive solutes and vitamin B9 in aqueous medium by physico-chemical contrivances

Abstract

Molecular interaction prevailing in α-amino acids (glycine, L-alanine, L-valine) and aqueous solution of folic acid (FA) has been reported by physico-chemical properties as density (ρ), viscosity (η), refractive index (n_D) and ultrasonic speed (u) at 298.15 K. The extent of interaction (solute–solvent interaction) is expressed in terms of the limiting apparent molar volume (φ⁰_V), viscosity B-coefficient, molar refraction (R_M) and limiting apparent molar adiabatic compressibility (φ⁰_K). The trends in transfer volumes, Δφ⁰_V, have been interpreted in terms of solute–cosolute interactions on the basis of a co-sphere overlap model. The role of the cosolute (FA), and the contribution of solute–solute and solute–solvent interactions to the solution complexes, has also been analysed through the derived properties.

Keywords:

• molecular interaction
• amino acids
• folic acid
• physico-chemical properties

Additional information

Funding

The authors are grateful to the Departmental Special Assistance Scheme, Department of Chemistry, NBU under the University Grants Commission, New Delhi [grant number 540/27/DRS/2007, SAP-1] for financial support and instrumental facilities in order to continue this research work. One of the authors, Prof. M.N. Roy, is thankful to University Grant Commission, New Delhi, Government of India, for being awarded one-time grant under Basic Scientific Research [grant-in-aid number F.4-10/2010 (BSR)] regarding his active service for augmenting of research facilities to facilitate further research work.