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Original Articles

GONAD REGRESSION INDUCED BY LSD AND ITS REDUCTION BY VITAMIN B2 AND VITAMIN B6 IN FRESH-WATER PLANARIAN, DUGESIA LUGUBRIS (SCHMIDT)

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Pages 1-6 | Received 12 Sep 1975, Published online: 12 Jul 2013
 

SUMMARY

Neurosecretory processes, which in planarians regulate many important biological activities, are hindered by some neuro-drugs containing in their molecule either a benzenic nucleus (as in amphetamine and its analogs) or an indolic nucleus (as in LSD and its analogs). In this way, amphetamine inhibits the regenerative phenomena of the cephalic region in beheaded planarians, while LSD (lysergic acid diethylamide) provokes the disappearance of the hermaphrodite genital apparatus in sexually mature specimens. Both these pharmacological effects may be appreciably attenuated by means of a contemporary administration of Vitamin B2 or Vitamin B6. In particular. Vitamin B2 appreciably attenuates the amphetamine effects, while the effects of LSD are attenuated partially by Vitamin B2 and more efficaciously by Vitamin B6.

RIASSUNTO

I processi neurosecretori, che nelle planarie regolano numerose ed importanti attività biologiche, vengono ostacolati da alcuni psico-farmaci contenenti nella loro molecola un nucleo benzenico (anfetamina e suoi analoghi) o un nucleo indolieo (LSD e suoi analoghi). Con tale meccanismo, l'anfetamina inibisce i processi rigenerativi della regione cefalica in planarie decapitate e l'LSD (dietilamide dell'acido lisergico) provoca la scomparsa dell'apparato genitale ermafrodita in esemplari sessualmente maturi. Questi effetti farmacologici vengono sensibilmente attenuati mediante una contemporanea somministrazione di Vitamina B2 o di Vitamina B6. In particolare, la Vitamina B2 attenua sensibilmente l'azione dell'anfetamina, mentre l'effetto dell'LSD viene attenuato parzialmente dalla Vitamina B2 e in misura più marcata dalla Vitamina B6.

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