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SUMMARY
This investigation is concerned with the determination of the toxicity of a number of species of Amanita to guinea pigs.
Alcoholic extracts of A. chlorinosma, A. cothurnata, A. flavivolva, A. mutabilis, A. neglecta, A. praegraveolens, and A. roanokensis were injected subcutaneously into guinea pigs without the appearance of any symptoms. It is concluded that these species are not-toxic by this method of testing.
Alcoholic extracts of A. verna, A. verniformis, and A. virosi-formis were injected subcutaneously into each of two guinea pigs, resulting in the death of both animals in each case within forty-eight hours. Autopsies were performed upon these animals, and the gross pathological changes noted include failure of the blood to clot, hemorrhage of the intestinal tract, anuria, and extensive pin-point hemorrhages of the liver.
The symptoms indicate the presence of Amanita-toxin in each of these species. The rapid onset of symptoms and paralysis noted in the animals injected with A. verniformis suggests the presence in this species of an additional toxic principle affecting the central nervous system.