SUMMARY
It was possible to cause selective damage to an area as small as 1 μ in diameter within the cell of Basidiobolus ranarum with a laser microbeam without the addition of dyes. Irradiation of the cytoplasm at the tip of the cell often resulted in an arrest of cellular elongation and frequently rupture of the tip. In some cases where nuclei were irradiated during anaphase, smaller nuclei were formed which were capable of division. A single shot into the phragmoplast stopped its development. The destruction of one daughter nucleus also stopped septum formation. The nucleolus appeared to be more sensitive to laser irradiation than the adjacent nuclear sap. A chromosome bridge was observed at mitosis following the irradiation of a resting nucleus. A mutant cell with two tips resulted from the irradiation of a nucleus.