ABSTRACT
Addition of sodium orthovanadate to the growth medium of Schizophyllum commune caused a decrease in the radial growth rate of surface colonies. Acid phosphatase activity was not significantly affected by the addition of vanadate except at high concentrations. Similarly, no differences were found in the isozyme patterns of acid phosphatase between controls and vanadate-grown colonies. In contrast, acid phosphatase extracted from colonies was very sensitive to inhibition by vanadate; 0.1 mM vanadate inhibited 90% of the enzyme activity. The differences may relate to transport of vanadate into the fungal cells.