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Summary
A dose of 75 ml of heavy liquid paraffin (British Pharmacopoeia) given twice daily for 26 days to 3 cows in the declining stages of lactation, had no detectable effect on the plasma prothrombin times as measured by a modification of Quick's one-stage method using human brain as the source of thromboplastin.
The same dose rate of oil given to 7 cows in late pregnancy, or late pregnancy and the first two weeks after calving, was also without effect.
The average prothrombin time in the first experiment was 23.0 sec (48 samples) and in the second experiment, 21.6 sec (145 samples). These figures were of the order of values found by other investigators for bovine plasma, but were rather higher than those for the normal human-plasma standards (14-16 sec).