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The essential pathology of facial eczema in the sheep is an acute cholangitis which in severe, acute, or chronic cases proceeds to obliteration of the duct by fibrous tissue. This btter phenomenon is immediately followed by ductule hyperplasia, canalicular infarction and hepatocellular necrosis and later by cicatrisation of those areas drained by obliterated bile ducts and compensatory hyperplasia of the non-affected portions of the liver.
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