Three-Component Mannich Reaction of Aromatic Ketones, Aldehydes and Amines Catalyzed by Reusable Aluminium Methanesulfonate

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Notes

^aReaction conditions: acetophenone (11 mmol), benzaldehyde (10 mmol), aniline (10 mmol), catalyst (0.5 mmol), EtOH (5 mL), room temperature.

^bCatalyst was reused four times.

^aReaction conditions: acetophenone (11 mmol), benzaldehyde (10 mmol), aniline (10 mmol), Al(CH₃SO₃)₃·4H₂O (0.5 mmol), solvent (5 mL), room temperature, 8 h.

^aThe structures of all the products were characterized by mp., ¹H NMR, IR, MS and elemental analysis. The physical and spectroscopic data of our known samples were identical with those reported in the literatures.

^bIsolated yields.