Solubility of budesonide in {ethanol + water} mixtures from T = (293.2 to 313.2) K: Experimental measurement and mathematical modelling

ABSTRACT

The solubility of budesonide (BDS) in binary mixtures of ethanol and water at T = (293.2–313.2) K is determined and mathematically represented using two cosolvency models, i.e. Jouyban–Acree model and Jouyban–Acree–van’t Hoff model. The mean relative deviations for fitting the solubility data of BDS in binary mixtures of ethanol + water are 6.6% and 6.5%, respectively. Furthermore, the apparent thermodynamic properties, dissolution enthalpy, dissolution entropy, and Gibbs free energy change of dissolution process of BDS in all the mixed solvents were calculated according to van’t Hoff and Gibbs equations. Dissolution of BDS in these mixed solvents is an endothermic process.

KEYWORDS:

• Solubility
• budesonide
• ethanol
• binary solvent mixture
• Jouyban–Acree model
• van’t Hoff equation

Acknowledgements

Research reported in this publication was supported by Elite Researcher Grant Committee under grant number 943610 from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Research reported in this publication was supported by Elite Researcher Grant Committee under grant number 943610 from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.