http://orcid.org/0000-0002-4008-7273
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ABSTRACT
The solubilities of bosentan (BST) in binary aqueous mixtures of 2-propanol at temperatures ranging from 293.15 to 313.15 K were determined using a shake-flask method. The produced data were modelled with the Jouyban-Acree-van’t Hoff model and difference between the predicted data and experimental ones were illustrated by percent average relative deviations (%ARD). Moreover, the thermodynamic functions of dissolution for BST in the aqueous 2-propanol solutions were computed which suggest that the dissolution process is endothermic and not spontaneous.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
S. N. Mirheydari would like to thank for a postdoctorate grant [693118] of Tabriz University of Medical Sciences for supporting this work.