Measurement and modelling of solubility data for bosentan in 1-propanol + water mixtures at various temperatures

ABSTRACT

The experimental solubility determination of bosentan (BST) in 1-propanol + water mixtures within temperature range, T = (293.15–313.15) K were performed by applying the shake-flask method. The solubility data were correlated by four cosolvency models, which are the Jouyban-Acree, Jouyban-Acree-van’t Hoff, modified Wilson, and Yalkowsky equations. The back-calculated solubility using the Jouyban-Acree-van’t Hoff equation presents better compatibility with the experimental data than those by the other models. Thermodynamic properties such as apparent molar enthalpy, entropy, and Gibbs free energy change of BST dissolution process in the binary (1-propanol + water) mixtures were also calculated which indicative of the inspontaneous process of dissolution.

KEYWORDS:

• Solubility
• bosentan
• 1-propanol
• Jouyban-Acree model
• modified Wilson model

Acknowledgments

S. N. Mirheydari would like to thank for a postdoctorate grant (693118) of Tabriz University of Medical Sciences, Iran for supporting this work.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Tabriz University of Medical Sciences [693118].