A New Approach to Increasing Tolerance to Oral Aminophylline

Abstract

A new approach to increasing tolerance to oral aminophylline therapy is reported. It consists of giving, together with aminophylline, a nonabsorbable, sodium-free antacid in the form of aluminum hydroxide gel. This mixture greatly reduces the irritating effect of aminophylline on the gastrointestinal tract without interfering with its absorption. It permits the administration of larger doses of aminophylline for therapeutic purposes.