Multiple Smallpox Vaccinations in the Treatment of Recurrent Herpes Simplex

Abstract

On the basis of the study here reported, the authors conclude that multiple smallpox vaccinations are of value in the management of patients with recurrent herpes simplex. Of 68 cases reviewed, 52 patients (76.5 per cent) definitely had no subsequent attacks during a lengthy follow-up period; 7 patients were probably cured, and the recurring lesions in the remaining 9 patients were less severe than those preceding therapy with a longer interval between attacks. The specific mechanism for the benefit noted is not fully understood.