Natural History of the Nephrotic Syndrome in Glomerulonephritis

Abstract

It is not known whether the histologic renal changes in the nephrotic syndrome represent sequelae of classic acute glomerulonephritis or whether the nephrotic and non-nephrotic types of glomerulonephritis are different diseases. A tentative conclusion is reached, based on correlation of histologic and clinical observations in 22 cases, that the condition as defined herein is not a sequela of classic acute glomerulonephritis but a separate disease. The probable sequence of structural glomerular changes is described.