Diuretic Effects of Flumethiazide, a Benzothiadiazine Derivative

Abstract

Flumethiazide is a potent diuretic agent which may be safely administered to cardiac patients.

Both short-term and long-term studies of a large group of patients with congestive heart-failure showed that flumethiazide produced no significant change in the glomerular filtration rate, renal plasma flow or blood pressure.

Bio-assay studies revealed that flumethiazide produced a marked natruretic effect. With a therapeutic dose of from 200 to 2000 mg., the sodium excretion in response to flumethiazide was similar to that resulting from administration of chlorothiazide.