Thyroxin Analogs and Their Place in Therapy

Abstract

Recent discovery of several naturally occurring thyroxin analogs has led to the study of a number of synthetic compounds having thyromimetic activity. The place of these thyroxin analogs in therapy is described in relation to replacement therapy for hypothyroidism (use of L-triiodothyronine compared with desiccated thyroid and L-thyroxin) and to treatment of hypercholesteremia (experimental results with D-thyroxin, D-triiodothyronine, tetraiodothyroacetic and triiodothyroacetic acid, triiodothyropropionic acid, diiodothyroacetic acid and diiodothyroformic acid).