Evaluation of Librium® as a Preanesthetic Medication

Abstract

Librium, a new psychotherapeutic agent unrelated chemically or pharmacologically to other known tranquilizers or antidepressants, was administered in a dose of 25 or 50 mg. in combination with a sympathomimetic drying agent as preanesthetic medication to 400 patients undergoing elective surgical procedures. It alleviated apprehension effectively. Optimal results were achieved with the 50 mg. dose. There was no evidence of alteration in blood pressure, of respiratory depression, or of influence on anesthetic requirements.