Clinical Experience With Triparanol

Abstract

Results of an investigation conducted by the authors show that triparanol lowered serum cholesterol significantly and consistently in a large number of patients by inhibiting the synthesis of cholesterol in the liver and in other tissues.

The cholesterol-depressant effect of triparanol is independent of other fat partitions. Triparanol appears to be safe for general clinical use; however, 5 to 10 year follow-up studies must be made before its value in arteriosclerotic heart disease can be determined.