Some Aspects of the Natural History and Treatment of Chronic Glomerulonephritis

Abstract

Inapparent streptococcal infection may be complicated by equally inapparent (latent) glomerulonephritis which leads eventually to active chronic glomerulonephritis. Photomicrographs are presented illustrating the progression, in one year, from latent glomerulonephritis related to type 12 streptococci to an early nephrotic state with hypertension. The discouraging outlook of nephrotic glomerulonephritis in adults forces the consideration of heroic therapy with massive doses of corticosteroids, but it is not yet established whether or not such therapy is justified in latent chronic glomerulonephritis without the nephrotic state.