Idiopathic Thrombocytopenic Purpura

Abstract

The acute form of ITP may be drug-induced or may follow infection or exposure to chemicals. The chronic form represents a self-perpetuating immunologic (auto-immune) disorder, at times associated with chronic lymphatic leukemia and other disorders. In some cases, it may be a prodrome of systemic lupus, to which it seems to be closely related. Therapy of acute ITP is “expectant,” with use of platelet transfusions and corticosteroids paramount; splenectomy should almost never be done. Chronic ITP may be treated for a few months or even years with corticosteroids; in about 25 per cent of cases splenectomy ultimately will be necessary.