Abstract
Many patients with arteriosclerosis obliterans of the aorto-iliac region (the Leriche syndrome) can be treated conservatively. Indications for radical surgical intervention include rapid progression of symptoms and the appearance of ulceration, gangrene, or severe pain at rest. In a series of 700 patients, arterial reconstruction by grafting (performed in 65 per cent) was highly successful and lowered the amputation rate from 10 per cent to 3 per cent. Research should continue to develop better graft materials.