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Abstract
5-Iodo-2′-deoxyuridine (IDU) is the first therapeutic antiviral agent with proved activity in animals and man. It is useful in treating keratitis caused by herpes simplex virus and vaccinia. By competitively reversing the deleterious effects of corticosteroids on corneal virus infection and by protecting the cornea, it aids anti-inflammatory therapy of deeper disease. IDU-resistant virus occurs, but cytosine arabinoside appears effective in this case. It seems likely that an agent therapeutically effective against viral disease must act either on the terminal virus-specific stages of DNA synthesis or on the assembly of the virus.