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Abstract
A comparative analysis was made of the efficacy of prophylactic castration in 79 patients with breast cancer (performed at the time of initial tumor therapy) versus therapeutic castration in 96 patients (performed when cancer recurred). The interval from initial therapy to recurrence of cancer was greater in the prophylactic group. The interval from recurrence of cancer to death was greater in the therapeutic group. The total survival time from initial therapy to death was not significantly different in the two groups.