Gamma Globulin in Pediatrics

Abstract

Gamma globulin is of value as a prophylactic or modifying agent in selected cases of measles, pertussis, infectious hepatitis (particularly in adults), congenital agammaglobulinemia, and rubella occurring during the first four months of pregnancy. Specific hyperimmune globulins have been found beneficial in mumps, smallpox, tetanus, eczema vaccinatum, etc.

Clinical trials have shown that gamma globulin has little value in treatment of acute infections in childhood, with the exception of pertussis. Long-term administration on the basis of a single low serum determination of gamma globulin during a period when it is physiologically low should be avoided.