Turner's Syndrome (Gonadal Dysgenesis)

Abstract

Possible mechanisms for the absence of one of the sex chromosomes in Turner's syndrome are anaphase lag and nondisjunction during miosis. Mosaic chromosomal patterns may result from accidents in mitosis of the fertilized egg. The sex chromatin pattern is a valuable aid in diagnosis. Individuals with Turner's syndrome are no longer considered genetic males. The clinical picture is reviewed, and recommendations for treatment are given.