Abstract
Multiple sclerosis is the most common of the demyelinating diseases. Initially, there are circumscribed areas of myelin destruction in the white matter of the brain and spinal cord, along with a varying amount of cellular proliferation. The endogenous or exogenous factors responsible are unknown. No specific therapy will alter the course of the disease. In an acute exacerbation, fairly complete rest is desirable. Physiotherapy is of limited value.
Other demyelinating diseases with a pathogenesis similar to that of multiple sclerosis are diffuse sclerosis, neuromyelitis optica and acute disseminated encephalomyelitis.