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Postgraduate Medicine Volume 40, 1966 - Issue 2
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Original Articles

Pedigree Analysis

2. Clinical Discrepancies and Limitations

Kenneth L. BeckerVeterans Administration Hospital, Washington, D. C.
, M.D.
Pages 171-174 | Published online: 18 Apr 2016
 
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Abstract

The basic reasons for the discrepancy between predicted and observed ratios or patterns of inheritance of genetic traits are related to penetrance and expressivity. Difficulties in collection and ascertainment of human data pose additional problems in pedigree analysis.

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