Syndromes Primarily Associated With Abnormalities of Bilirubin Metabolism

Abstract

Recently acquired knowledge of bilirubin metabolism has clarified the pathogenesis of many inherited types of jaundice but has contributed little to an understanding of the mechanisms responsible for jaundice in acquired diseases of the liver. The hepatic metabolism of bilirubin is reviewed, and syndromes associated with abnormalities of bilirubin metabolism are enumerated under two headings: unconjugated hyperbilirubinemia and conjugated hyperbilirubinemia.