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Abstract
An intensive search continues for effective, nontoxic drugs for rheumatoid arthritis and other inflammatory diseases. Of the newer drugs, indomethacin appears of most value so far. Other agents, such as dimethylsulfoxide, an indomethacin analogue, cytotoxic drugs, immunosuppressive agents and anthranilic acid derivatives, are still experimental. Older drugs still have a definite place. In certain cases of gout, both indomethacin and allopurinol have proved useful.