Abstract
A comparative study of 98 cases of myeloid metaplasia and 93 cases of chronic granulocytic leukemia suggests a common pathogenetic mechanism. The laboratory procedures most helpful in differentiation were leukocyte alkaline phosphatase determinations and cytogenetic studies. Acute leukemia occurring in four cases of myeloid metaplasia supports the theory that polycythemia vera, myeloid metaplasia, and chronic and acute granulocytic leukemia constitute a spectrum of myeloproliferative disorders.